Major Neurones in GIT Plexi


Cholinergic Nerve Endings

  • extrinsic parasympathetic and intrinsic
  • essential for maintenance of normal motiliy pattern
Adrenergic Nerve Endings
  • entirely extrinsic
  • generally relax GIT by the inhibitory effect of noradrenaline on the neurones of the enteric system
  • strong sympathetic stimulation can block movement


Non-Adrenergic, Non-Cholinergic (NANC) Nerve Endings

  • enteric ganglia mainly secrete Vasoactive Intestinal Peptide (VIP), Nitric oxide
  • relax smooth musculature of intestinal tract below bolus of food