Most of the Glucose, amino acids and HCO₃^- are reabsorbed at the proximal tubule by sodium dependent transport system. With this system, these compounds are transported by a carrier that derives its energy from the sodium concentration gradient. Thus these compounds are indirectly transported by energy utilised in the sodium/potassium pump.

Glucose and amino acids are reabsorbed in the first 20 - 30% of the proximal tubule. The HCO₃^- ion reabsorption is secondary to and dependent on the secretion of Hydrogen ion in exchange for the sodium reabsorption.

60 to 70% of Potassium and Calcium ions are reabsorbed at the proximal tubule by both passive and active diffusion.