-
Gastric epithelium is liable to be attcked by acid
and gastric enzymes but it is protected by a thick alkaline mucus
that is secreted by the surface epithelium.
-
protective barrier between the epithelium and the
acid and pepsin in the gastric lumen
-
mucus is heavily glycosylated to protect it from proteolysis
by pepsin
-
mucus layer is also buffered by HCO3 secreted by the
epithelial cells that produces a protective pH gradient across the
mucus layer
|