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Vitamin D is a steroid hormone that is important
in regulating the body levels of calcium and phosphorus, and in the
mineralization of bone.
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Receptors for vitamin D hav
ealso been found in a wide variety of cells, and thus this hormone
has biologic effects which extend far beyond control of mineral metabolism.
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The term vitamin D refers to a group of steroid molecules.
Cholecalciferol, Vitamin D3, can be produced in the skin of animals
when light energy is absorbed by a precursor molecule 7-dehydrocholesterol.
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Dietary sources of vitamin D,
include egg yolk, fish oil and a number of plants. However, natural
diets typically do not contain adequate quantities of vitamin D, and
exposure to sunlight or consumption of foodstuffs purposefully supplemented
with vitamin D are necessary to prevent deficiencies.
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Vitamin D3 (and the plant Vitamin D2) does not have
significant biological activity. It is thus metabolized within the
body to the hormonally-active form. This transformation occurs in
two steps one within the liver where cholecalciferol is hydroxylated
to 25-hydroxycholecalciferol by the enzyme 25-hydroxylase.
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The next step involves the kidney where 25-hydroxycholecalciferol
is further hydroxylated to 1,25-dihydroxycholecalciferol, the biologically
active form of vitamin D, by the enzyme 1-alpha-hydroxylase.
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All forms of vitamin D are hydrophobic, and are transported
in blood bound to carrier proteins. The major carrier is called, appropriately,
vitamin D-binding protein.
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Physiologic Effects
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Similar to other steroid hormones, vitamin D binds
to intracellular receptors that then function as transcription factors
to modulate gene expression.
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Vitamin D is involved in mineral metabolism and bone
growth.
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It facilitates intestinal absorption of calcium, phosphate
and magnesium ions. In the absence of vitamin D, dietary calcium is
not absorbed at all efficiently.
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Vitamin D acts as a transcriptional
regulator of bone matrix proteins, it induces the expression of osteocalcin
and suppresses synthesis of type I collagen.
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In cell cultures, vitamin D stimulates differentiation
of osteoclasts.
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Vitamin D provides the proper
balance of calcium and phosphorus to support mineralization.
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Control of Vitamin D Synthesis
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Blood levels of 25-hydroxycholecalciferol
largely reflect the amount of amount of vitamin D produced in the
skin or ingested. Ont the other hand, the activity of 1-alpha-hydroxylase
in the kidney is tightly regulated and serves as the major control
point in production of the active hormone.
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Major inducers of 1-alpha-hydroxylase
is parathyroid hormone and low blood levels of phosphate.
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